Signature formulation · Beauty & Longevity

EXOSOME
MATRIX DRINK

A multi-ingredient Japanese beauty drink bringing together a PUA exosome-containing extract, food-derived nucleotides, fermented collagen, fermented placenta concentrate and selected beauty nutrients.

12bottles30 mLeachMade in Japan

EXOSOME MATRIX DRINK bottle and open presentation box by Yotsuba Japan

Why it was created

Beauty is not only
what appears at the surface.

Skin appearance reflects a network of structural, barrier and nutritional processes working together. EXOSOME MATRIX DRINK was conceived in Japan as a concentrated daily ritual for that wider biological picture—not as another single-ingredient collagen drink.

Its architecture brings together a signature PUA exosome-containing extract, food-derived nucleotides, fermented collagen peptides, fermented and aged placenta concentrate, rice ceramides and selected beauty nutrients. Each layer has a distinct role; together they form a considered matrix designed for premium beauty and longevity portfolios.

A considered Japanese multi-ingredient approach

Woman enjoying EXOSOME MATRIX DRINK as part of her daily beauty ritual

Cell biology · extracellular vesicles

Small carriers.
Complex conversations.

A closer look at how cells release membrane-bound vesicles and how their molecular cargo can participate in communication between cells.

Explore ingredient evidence

YOTSUBA JAPAN FORMULA STUDY

01/ 03

Release

A source cell releases extracellular vesicles enclosed by a lipid membrane.

General vesicle biology. Delivery to tissues and effects after consuming this drink are not established by this illustration.

Formula architecture

Signals, structural nutrients
and a considered beauty matrix.

Pearlescent extracellular vesicles representing the exosome powder platform

Signal platformThe PUA exosome-containing extract anchors the concept of extracellular communication—the biological language that inspired the formula.

A delicate rice panicle representing the plant-derived rice ceramides

Structural beautyRice ceramides, fermented collagen peptides and hyaluronic acid support the formula’s structure-and-hydration design.

A silver salmon representing the source of food-derived DNA-Na

Nucleotide matrixSalmon-milt-derived DNA-Na and yeast-derived RNA bring a complementary food-derived nucleotide layer.

An elegant horse representing fermented horse placenta extract

Japanese bioactive complexFermented horse placenta extract, RG92 green algae, royal jelly, CoQ10 and B vitamins complete the architecture.

Inside the formula

Every ingredient has
a defined role.

Quantities shown are based on the current 30 mL bottle label and product dossier supplied by Yotsuba Japan. Market labels may differ.

Salmon Milt Extract

Food-derived nucleotide source containing DNA-Na 86%.

250 mg

Yeast Extract

Food-derived nucleotide source containing RNA 85.2%.

250 mg

Fermented Collagen Peptide

Low-molecular-weight collagen peptides produced through a fermentation-led process.

200 mg

Fermented & Aged Placenta Concentrate Extract

Equivalent to 2,880 mg of pure placenta; included as a peptide and amino-acid layer.

120 mg

PUA Exosome-Containing Extract

Placenta, umbilical-cord and amniotic-fluid extract containing exosome; the source material is standardised at ≥218 billion particles / g.

60.70 mg

Rice Extract Containing Ceramide

Plant-derived ceramides selected for the skin-barrier and hydration concept.

11 mg

Royal Jelly Extract

A complementary bee-derived beauty nutrient listed in the product supplement facts.

2.5 mg

Green Algae Extract RG92

RG92 is included as a Japanese green-algae support ingredient.

1 mg

Hyaluronic Acid

A hydration-focused structural beauty ingredient.

1 mg

Coenzyme Q10

Included as part of the formula’s complementary beauty matrix.

54 μg

Yucca Extract

Botanical support ingredient listed in the product supplement facts.

Listed without amount

B-Vitamin System

Amounts transcribed from the current box per 30 mL bottle.

Niacin 250 μg · calcium pantothenate 219 μg · B6 181 μg · B2 125 μg · folic acid 100 μg

EXOSOME MATRIX DRINK bottle with the open twelve-bottle presentation box

One formula · several complementary layers

Precision in every
layer of the matrix.

The formula is deliberate: several complementary ingredient systems brought together in a precise liquid composition. Its value is not one fashionable ingredient in isolation, but the logic of the complete matrix.

Individual 30 mL bottle12-bottle presentationConcentrated liquid ritual

Ingredient evidence library

Built for a more
informed conversation.

Important distinctionThese publications examine individual ingredients or related ingredient preparations. They are not clinical trials of EXOSOME MATRIX DRINK and do not prove that the finished product produces the same outcomes.

Equine placental extractHuman RCT

Facial skin quality in healthy adult women

A randomised, double-blind, placebo-controlled study in 29 women evaluated 220 mg/day for four weeks. The between-group pattern for cheek melanin index differed, while hydration and TEWL did not show a significant between-group difference.

Collagen peptidesHuman clinical study

Skin hydration and barrier-related measures

Oral collagen-peptide intake was associated with increased stratum-corneum and epidermal water content and reduced transepidermal water loss. Ingredient type and dose should be compared with the finished formula before extrapolation.

Rice ceramidesHuman prospective study

Skin barrier function and hydration

A prospective study assessed oral rice-derived ceramides in relation to skin-barrier measures. The design was open-label, so it provides supportive—not confirmatory—clinical evidence.

Food-derived DNA-NaPreclinical

Stress-related inflammatory signalling

A mouse study found changes in stress-related and hippocampal inflammatory markers with salmon-milt-derived DNA-Na. This is mechanistic animal evidence and cannot establish a human clinical benefit.

Professional product data

Complete details,
clearly organised.

The quantitative active formula is presented above. Here, professionals can review the complete ingredient declaration, allergens, format, nutrition information, directions and handling information.

Complete ingredients & allergens01

Current Japanese composition: Isomaltooligosaccharide syrup, reduced maltose syrup, erythritol, salmon milt extract, yeast extract (containing RNA), fermented collagen peptide (fish gelatin, pineapple juice), fermented and aged placenta extract concentrate powder, malt extract, placenta / umbilical-cord / amniotic-fluid extract, peach juice, rice extract containing ceramides, rose water, royal jelly extract, rose bud extract powder, green algae extract, coenzyme Q10, acidulants, flavouring, chilli pepper extract, thickener (xanthan gum), yucca extract, hyaluronic acid, sweetener (stevia), niacin, spice extract, calcium pantothenate, vitamin B6, vitamin B2 and folic acid.

Allergen information: Contains salmon, fish gelatin and peach. Royal jelly may cause an allergic reaction in sensitive individuals. The approved market-specific label remains authoritative.

Format & serving02

Product category Beverage with 20% mixed fruit juicePackage 360 mL totalPresentation 12 bottles × 30 mLServing unit 1 bottleSuggested use 1 bottle every 1–2 daysServing note Best enjoyed chilled

Nutrition per 30 mL bottle03

Energy 14.5 kcalProtein 0.7 gFat 0 gCarbohydrate 7.9 gSalt equivalent 0.218 gNiacin 250 μgCalcium pantothenate 219 μgVitamin B6 181 μgVitamin B2 125 μgFolic acid 100 μgBasis Per 30 mL bottle

Use, storage & precautions04

Store away from high temperature and direct sunlight, in a cool place. Drink immediately after opening. If ingredients float or settle, this does not indicate a quality problem. People with food allergies should review the full ingredient declaration, and anyone for whom the product does not suit their constitution should stop use. Be careful not to injure yourself on the edge of the cap. This is a food supplement, not a medicine; a balanced diet remains the foundation of health.

日本MADE
IN JAPAN

Japanese quality & provenance

Designed as a flagship,
documented as a professional product.

Developed and manufactured in Japan with a dossier-led approach for international professional review. Manufacturing, specification and market documentation are provided through Yotsuba Japan’s official partner network, subject to destination-market requirements.

Frequently asked

Clear answers,
without overclaiming.

01What makes this different from a conventional collagen drink?+

EXOSOME MATRIX DRINK is not built around collagen alone. It combines a signature exosome-powder platform with food-derived nucleotides, fermented collagen peptides, rice ceramides and complementary beauty nutrients in one considered matrix.

02Who is the formula designed for?+

It was developed for premium beauty, healthy-ageing and professional wellness portfolios. Individual suitability should always be assessed against the destination-market label and, where appropriate, by a qualified professional.

03How should it be taken?+

The current label suggests one 30 mL bottle every one to two days, best enjoyed chilled. Follow the approved market-specific label for the destination market.

04Are the cited studies trials of this finished drink?+

No. The evidence library relates to individual ingredients or comparable ingredient preparations. It is included to explain the scientific rationale—not to claim that the finished product reproduces every published outcome.

05Where is it made?+

The formula is developed and manufactured in Japan. Product documentation for professional review is available from Yotsuba Japan and its official partners.

Food supplement · Not a medicine

Product information is educational and intended for professional portfolio review. It is not medical advice and is not intended to diagnose, treat, cure or prevent disease. Suitability, permitted claims and labelling must be assessed for each destination market.

EXOSOME MATRIX DRINK

A Japanese beauty ritual,
engineered beyond the ordinary.

Detailed product documentation is available to verified clinics, professionals and authorised partners, subject to individual review.Available exclusively through authorised Yotsuba Japan partners.