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Hair & nail · 30-day daily system
ANA GAIN™
NU
A Japanese hair-and-nail formula centred on AnaGain™ Nu organic pea-sprout extract, hydrolysed keratin, sulphur amino acids and Japanese botanical support.
90capsules3per dayMade in Japan
Why it was created
Beauty begins at
the growth matrix.
Hair and nails are keratin-rich structures. Their appearance reflects a complex interaction between the growth cycle, amino-acid availability, micronutrient status and daily care.
ANA GAIN™ Nu combines a studied pea-sprout active with hydrolysed keratin, L-cystine, L-methionine and a distinctly Japanese botanical-mineral layer.
Botanical research · hair-cycle context
A botanical beginning.
A gradual cycle.
The germinated-pea ingredient is placed in the context of a hair follicle and its naturally changing growth cycle.
Explore ingredient evidenceYOTSUBA JAPAN / FORMULA STUDY
01/ 03
Botanical origin
AnaGain™ Nu is a germinated-pea-derived ingredient studied in relation to the hair-growth cycle.
Illustrative ingredient study. Shapes and movement are simplified; product evidence is reviewed separately.
Formula architecture
One daily system.
Four beauty layers.
Inside the formula · per 3-capsule daily serving
Built around
100 mg AnaGain™ Nu.
Declared amounts follow the current Yotsuba Japan presentation for a three-capsule daily serving. Destination-market labels remain authoritative.AnaGain™ Nu
A water-soluble extract from organic germinated pea seeds and the signature botanical active in the formula.
Hydrolysed keratin
A keratin hydrolysate supplying a concentrated amino-acid profile for the formula’s structural nutrition layer.
L-cystine
A sulphur-containing amino acid and a structural component associated with keratin architecture.
L-methionine
An essential sulphur-containing amino acid included alongside cystine and hydrolysed keratin.
Camellia seed extract
Japanese Camellia japonica seed extract, sourced from a traditional Japanese botanical.
BioPerine®
A standardised black-pepper extract included as a bioavailability-supporting component.
Sesamin
A lignan supplied by the formula’s black-sesame extract.
Iodine
Naturally sourced from gagome kombu, a marine botanical traditionally harvested in Hokkaido.
Zinc
Provided by zinc-enriched yeast as part of the formula’s mineral support system.
Vitamin B1
Thiamine included within the supporting B-vitamin complex.
Vitamin B2
Riboflavin included within the supporting B-vitamin complex.
Vitamin B6
A B vitamin involved in normal protein and glycogen metabolism.
Biotin
A beauty-relevant micronutrient included in the daily formula.
Vitamin B12
Cobalamin included within the supporting B-vitamin complex.
Vitamin E
An antioxidant vitamin supplied through vitamin E-containing vegetable oil.
Calcium pantothenate
The calcium salt of pantothenic acid used as the formula’s vitamin B5 source.
Hair, nails and the daily nutrition ritual
Botanical signal.
Structural nutrition.
The product brings several complementary ideas into one daily serving: the pea-sprout active, keratin-building amino acids, a Japanese camellia layer and supporting marine, mineral and botanical ingredients.
Compact capsule formatThree-capsule daily serving30-day beauty ritual
Ingredient evidence library
Evidence, with the
right boundaries.
Important distinctionThe sources below examine individual ingredients, preclinical models, different formulas or non-equivalent doses. They are not clinical trials of the complete ANA GAIN™ Nu product.
AnaGain™ NuPilot human study
Oral pea-sprout extract and hair shedding
A small nutrition intervention enrolled 21 volunteers and evaluated 100 mg daily for eight weeks. Hair shedding was significantly reduced after 28 days. The study was small and linked to the ingredient developer.
Pea-sprout extractPreclinical mechanism study
Pea-sprout extract and follicle signalling
A 2025 study used human dermal-papilla cells, macrophage cells and a mouse model to examine Wnt/β-catenin signalling, growth-factor expression and anagen-phase biology. It adds mechanistic context, but it is not a human trial and does not establish an effect for this finished product.
Keratin hydrolysateIngredient-level RCT
Keratin nutrition, hair and nail parameters
A randomised trial evaluated a different keratin-based supplement at a materially higher dose. It supports the broader ingredient rationale, but it is not a trial of this formula and its results cannot be transferred directly.
L-cystine + B vitaminsRandomised double-blind trial
Cystine-containing combinations and diffuse shedding
A four-month trial in 72 women compared two B-vitamin and L-cystine combinations with placebo and assessed hair quality and anagen rates. One active combination outperformed placebo, but its composition differed from ANA GAIN™ Nu, so the result cannot be assigned to cystine alone.
BiotinRetrospective nail study
Biotin in people with brittle nails
A small retrospective study reported clinical improvement in 22 of 35 evaluated people with brittle nails. The study was uncontrolled and used a therapeutic context and dose that should not be equated with the 100 μg biotin in this daily formula.
Vitamins & mineralsClinical review
Micronutrients and hair-loss evidence
A dermatology review describes the relationship between micronutrient status and hair health while warning that supplementation is most relevant when a deficiency or clinical need is present.
Professional product data
Complete details,
clearly organised.
The quantitative active formula is presented above. Here, professionals can review the complete ingredient declaration, allergens, format, nutrition, directions and handling information.Complete ingredients & allergens01
Current Japanese composition: pea sprout extract powder (isomaltooligosaccharide, pea sprout extract; manufactured in Switzerland), hydrolysed keratin preparation (hydrolysed keratin, dextrin), zinc-containing yeast, gagome kombu powder, camellia seed extract, vitamin E-containing vegetable oil, black pepper extract, black sesame extract containing sesamin, crystalline cellulose, L-cystine, HPMC, L-methionine, calcium pantothenate, silicon dioxide, calcium stearate, caramel colour, modified starch, vitamin B6, vitamin B2, vitamin B1, biotin and vitamin B12.
Allergen information: Contains sesame. The approved market-specific label remains authoritative.
Format & daily serving02
Format 90 capsulesDaily serving 3 capsulesSupply 30 daysNet content 39.15 gCapsule weight 435 mgCapsule fill 360 mg
Nutrition per daily serving03
Energy 4.83 kcalProtein 0.58 gFat 0.02 gCarbohydrate 0.57 gSalt equivalent 0.0127 g
Nutrition values are stated per three capsules (1.305 g).
Use, storage & precautions04
Take three capsules daily with water or warm water according to the current Japanese directions. Store away from high temperature, humidity and direct sunlight. Contains gagome kombu, a naturally iodine-containing marine ingredient. Individuals receiving medical treatment, and anyone who is pregnant, breastfeeding or managing a thyroid condition or iodine restriction, should consult an appropriate healthcare professional before use. This is a food supplement, not a medicine.
日本MADE
IN JAPAN
IN JAPAN
Japanese quality & provenance
A Swiss botanical active,
completed in Japan.
The signature AnaGain™ Nu raw material is produced from organic germinated pea seeds. The finished formula combines it with Japanese and international ingredients and is manufactured in Japan for professional export channels.
Frequently asked
Clear answers,
without overclaiming.
01What is AnaGain™ Nu?+
AnaGain™ Nu is a water-soluble powder extract produced from organic germinated pea seeds. It is the signature botanical active in this formula.
02What is the daily serving?+
The current Japanese product directions indicate three capsules daily. Always follow the approved destination-market label.
03Is the keratin plant-based?+
No. The hydrolysed keratin is not plant-based. The capsule shell listed in the current Japanese composition is HPMC rather than gelatin.
04Does the product contain iodine?+
The formula contains gagome kombu, a marine ingredient that naturally contains iodine. People with thyroid conditions or specific iodine restrictions should seek professional advice before use.
05Are the cited studies trials of the finished product?+
No. The evidence shown concerns individual ingredients or other formulations and doses. It explains the scientific rationale, not a guaranteed effect of this finished product.
Food supplement · Not a medicine
Product information is educational and intended for professional portfolio review. It is not medical advice and is not intended to diagnose, treat, cure or prevent disease. Suitability, permitted claims and labelling must be assessed for each destination market.ANA GAIN™ Nu · Hair & Nail